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. 2019 Sep;47(9):983–994. doi: 10.1124/dmd.119.087312

Fig. 5.

Fig. 5.

Functional investigation of the AHRR GNF-351–dependent PGx-eQTL. (A) The GNF-351–dependent PGx-eQTL for AHRR was in intron 3 of the AHRR gene and contained rs1877843, which was 241 bp from peak 13160. (B) The variant rs1877843 SNP genotype was associated with a larger decrease in AHRR expression after GNF-351 treatment than the wild-type SNP genotype. (C) Luciferase plasmids that contained the variant SNP genotypes for rs1877843 and rs1877840 demonstrated a larger decrease in luciferase activity after GNF-351 treatment compared with luciferase plasmids containing the wild-type SNP genotypes in all three cell lines. The number of samples (N) for each group is at the bottom of each plot. All tests for significance used a two-tailed Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001.