TABLE 1.
PK parameters using NCA for plasma MPL in the study cohorts after intramuscular administration
| Experimental Group (n) | λz (h−1) | T1/2_λz (h) | Cmax (ng/ml) | AUC0-∞ (h × ng/ml)b | CL/F (ml/h per kilogram) |
|---|---|---|---|---|---|
| Cohort 1: estrus female (30) | 0.24 | 2.9 | 5348 ± 488 | 10,489 ± 1054 | 4767 ± 479 |
| Cohort 2: proestrus female (39) | 0.27 | 2.6 | 3859 ± 777 | 9142 ± 646 | 5469 ± 386 |
| Cohort 3: noncycler female (20) | 0.20 | 3.4 | 3796 ± 188 | 8735 ± 601 | 5723 ± 394 |
| Cohort 4: male 7 wk (31) | 0.25 | 2.7 | 1470 ± 109 | 2808 ± 167 | 17,806 ± 1059 |
| Cohort 5: male 11 wk (23) | 0.26 | 2.6 | 1054 ± 94 | 2885 ± 312 | 17,334 ± 1875 |
| All females | 0.24 | 2.9 | 4204 ± 323 | 9751 ± 482 | 5128 ± 252 |
| All males | 0.28 | 2.5 | 1174 ± 194 | 2901 ± 185 | 17,232 ± 1099 |
CL/F, clearance; T1/2, half-life.
a
Values represent mean ± S.E.
b
AUC calculated using Bailer’s method for sparse (destructive) sampling.