Skip to main content

View full-text article in PMC

. 2019 Aug;370(2):327–336. doi: 10.1124/jpet.119.257527

TABLE 3.

PD parameter estimates for plasma CST suppression by MPL

Parameter	Definition	Estimate (% CV)
Circadian Rhythm Parameters for CST
T (h)	Biorhythmic period	24^a^,^b^,^c
a₀	Fourier coefficient	115.7^a^,^b/254.4^b
a₁		−120.9^a^,^b/−168.7^b
a₂		38.8^a^,^b/56.9^b
b₁		−41.1^a^,^b/−95.6^b
b₂		1.6^a^,^b/29.1^b
Pharmacodynamic Parameters
k_deg,CST (h⁻¹)	Loss rate constant for CST	1.38 (12.6)^a^,^b^,^c
τ (h)	Time to CST_stress	0.34 (12.8)^a^,^b^,^c
CST_stress (ng/ml)	Maximal CST due to stress	535 (18.0)^a/1292 (13.3)^b/1397 (12.9)^c
IC_50,CST (ng/ml)	Half-maximal inhibition concentration	3.4 (47.6)^a/41.6 (48.0)^b/12.9 (45.6)^c

^{^a}

Male.

^{^b}

Estrus female.

^{^c}

Proestrus female.