Table 1.
Neuroprotective effect of SNL on mitochondrial enzyme complexes (Complex I, II and V) and CoQ10 in ALB induced ICH-IVH in rats.
| Groups | Complex- I (nM/mg protein) | Complex-II (nM/mg protein) | Complex-V (nM/mg protein) | CoQ10 (nM/g protein) |
|---|---|---|---|---|
| Sham Control | 14.0 ± 0.25 | 9.03 ± 0.24 | 735.0 ± 7.755 | 7.28 ± 0.06 |
| SNL60 perse | 14.1 ± 0.30 | 9.06 ± 0.19 | 735.0 ± 6.703 | 7.38 ± 0.15 |
| ALB | 2.83 ± 0.30* | 1.20 ± 0.20* | 226.8 ± 4.564* | 0.83 ± 0.09* |
| ALB + SNL40 | 4.50 ± 0.42# | 2.23 ± 0.19# | 329.0 ± 16.48# | 1.91 ± 0.23# |
| ALB + SNL60 | 6.00 ± 0.25#@ | 3.23 ± 0.17#@ | 376.7 ± 6.652#@ | 2.63 ± 0.15#@ |
| ALB + SNL60+ CLB20 | 7.50 ± 0.42$ | 4.48 ± 0.09$ | 449.5 ± 9.986$ | 3.70 ± 0.21$ |
| ALB + SNL60+ MEM20 | 8.95 ± 0.09$ | 5.38 ± 0.17$ | 528.7 ± 5.993$ | 4.68 ± 0.08$ |
| ALB + SNL60+ DNP3 | 10.6 ± 0.33$ | 6.36 ± 0.15$ | 576.2 ± 7.981$ | 5.55 ± 0.13$ |
| ALB + SNL60+ PGB30 | 12.3 ± 0.21$β | 7.80 ± 0.22$β | 636.2 ± 17.36$β | 6.33 ± 0.08$β |
Data expressed as mean ± SEM (n = 6). * p < 0.05 versus sham control and SNL60 perse; # p < 0.05 versus ALB; #@ p < 0.05 versus ALB + SNL40; $ p < 0.05 versus ALB + SNL60; $β p < 0.05 versus DNP3, MEM20, and CLB20 (One way ANOVA followed by Tukey’s post hoc test).