Table 2.
Neuroprotective effect of SNL on neurotransmitter levels in ALB induced ICH-IVH in rats.
| Groups | Dopaminea | Glutamatea | Groups | GABAb |
|---|---|---|---|---|
| (ng/mg tissue) | (ng/mg tissue) | (ng/mg tissue) | ||
| Sham Control | 119.5 ± 8.097 | 84.67 ± 2.16 | Sham Control | 118.7 ± 7.508 |
| SNL60 Perse | 117.3 ± 6.159 | 85 ± 0.89 | SNL60 Perse | 116.7 ± 7.508 |
| AB | 11.97 ± 1.347* | 153.7 ± 3.77 | AB | 4.633 ± 1.793* |
| AB + SNL40 | 27.95 ± 7.844# | 129.2 ± 1.16 | AB + SNL40 | 16.3 ± 4.260# |
| AB + SNL60 | 44.7 ± 9.996#@ | 124 ± 2.098 | AB + SNL60 | 29.13 ± 4.507#@ |
| AB + SNL60 + CLB20 | 60.13 ± 10.40$ | 119.2 ± 2.04 | AB + SNL60 + CLB20 | 39.13 ± 4.507$ |
| AB + SNL60 + PGB30 | 75.92 ± 7.895$ | 111.8 ± 3.97 | AB + SNL60 + DNP3 | 51.63 ± 4.096$ |
| AB + SNL60 + DNP3 | 91.67 ± 5.837$ | 104.3 ± 1.862 | AB + SNL60 + MEM20 | 64.13 ± 6.400$ |
| AB + SNL60 + MEM20 | 107.7 ± 10.44$β | 92 ± 0.8944 | AB + SNL60 + PGB30 | 75.8 ± 6.047$β |
a
Data expressed as mean ± SEM (n = 6). * p < 0.05 versus sham control and SNL60 perse; # p < 0.05 versus ALB; #@ p < 0.05 versus ALB + SNL40; $ p < 0.05 versus ALB + SNL60; $β p < 0.05 versus DNP3, PGB30 and CLB20 (One way ANOVA followed by Tukey’s post hoc test).
b
Data expressed as mean ± SEM (n = 6). * p < 0.05 versus sham control and SNL60 perse; # p < 0.05 versus ALB; #@ p < 0.05 versus ALB + SNL40; $ p < 0.05 versus ALB + SNL60; $β p < 0.05 versus MEM20, DNP3 and CLB20 (One way ANOVA followed by Tukey’s post hoc test).