Table 5.
Neuroprotective effect of SNL on brain oxidative stress (SOD, nitrite concentration, GSH and lipid peroxidation (MDA)) in ALB induced ICH-IVH in rats.
| Groups | SOD | Nitrite | GSH | MDA |
|---|---|---|---|---|
| (U/mg) | (μg/mL) | (μmol/mg protein) | (nM/mg protein) | |
| Sham Control | 45 ± 1.414 | 301.5 ± 29.49 | 0.95 ± 0.024 | 0.5833 ± 0.487 |
| SNL60 perse | 43.67 ± 0.8165 | 309.7 ± 20.34 | 0.96 ± 0.027 | 0.7167 ± 0.479 |
| ALB | 12.67 ± 2.160* | 818.3 ± 35.60* | 0.01 ± 0.005* | 13.03 ± 1.193* |
| ALB + SNL40 | 17.67 ± 2.582# | 740.8 ± 21.28# | 0.16 ± 0.033# | 11.23 ± 1.120# |
| ALB + SNL60 | 22.67 ± 2.658#@ | 671.2 ± 58.72#@ | 0.31 ± 0.059#@ | 9.35 ± 0.7176#@ |
| ALB + SNL60 + CLB20 | 27.67 ± 3.141$ | 584.2 ± 21.56$ | 0.45 ± 0.126$ | 7.583 ± 0.9453$ |
| ALB + SNL60 + MEM20 | 32.83 ± 2.787$ | 517.3 ± 21.58$ | 0.61 ± 0.069$ | 5.833 ± 1.181$ |
| ALB + SNL60 + DNP3 | 37.83 ± 1.472$ | 442 ± 20.91$ | 0.75 ± 0.099$ | 4.033 ± 1.041$ |
| ALB + SNL60 + PGB30 | 42.67 ± 4.227$β | 373.2 ± 16.46$β | 0.91 ± 0.040$β | 2.033 ± 0.4590$β |
Data expressed as mean ± SEM (n = 6). * p < 0.05 versus sham control and SNL60 perse; # p < 0.05 versus ALB; #@ p < 0.05 versus ALB + SNL40; $ p < 0.05 versus ALB + SNL60; $β p < 0.05 versus DNP3, MEM20 and CLB20 (One way ANOVA followed by Tukey’s post hoc test).