Table 1.
Demographics and clinical characteristics of patients.
| N | Age | Sex | Risk Factors | Organism | Area of epithelial defect (mm2) | Area of stromal infiltration (mm2) | Depth of infection (um) | Length of SMT prior to first RB- PDAT (Weeks) | Initial BCVA | # of PDT treatments received | RB % | Successful (yes/no) | Time to clinical resolution after first RB-PDAT (Days) | Surgical intervention after RB-PDAT | Corneal graft status | BCVA last FU |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 23 | M | CL | Acanthamoeba | 30 | 48.2 | 243 | 12 | HM | 2 | 0.1 | Yes | 29 | PKP | Clear | 20/30 |
| 2 | 34 | M | CL | Acanthamoeba | 12 | 16 | 197 | 64 | HM | 2 | 0.1 | Yes | 30 | PKP, CE+ IOL | Clear | 20/200 |
| 3 | 32 | F | CL | Acanthamoeba | 40 | 40 | 387 | 16 | HM | 3 | 0.1 /0.2 | Yes | 60 | Keratectomy, PKP, CE+ IOL | Clear | 20/20 |
| 4 | 17 | F | CL | Acanthamoeba | 12.7 | 12.7 | 385 | 48 | LP | 1 | 0.1 | Yes | 30 | PKP | Clear | 20/60 |
| 5 | 55 | F | CL | Acanthamoeba | 38.5 | 31.2 | 116 | 3 | HM | 2 | 0.1 | Yes | 90 | CE +IOL, DALK | Clear | 20/60 |
| 6 | 48 | F | CL | Suspicious for Acanthamoeba | 14 | 14 | No data | 4 | HM | 2 | 0.1 | Yes | 60 | DALK, CE+ IOL | Clear | 20/30 |
| 7 | 57 | F | CL | Fusarium | 4.14 | 4.14 | 320 | 4 | HM | 2 | 0.1 | Yes | 20 | CE+ IOL, PKP | Clear | 20/100 |
| 8 | 83 | F | CL | Fusarium | 26 | 3.57 | 302 | 2 | 20/2000 | 1 | 0.1 | Yes | 60 | PKP | Clear | 20/800 |
| 9 | 37 | M | CL | Pseudomonas | 81 | 81 | 314 | 4 | LP | 1 | 0.1 | Yes | 27 | PKP, CE+ IOL | Clear | 20/30 |
| 10 | 62 | F | Soil/CL | Acanthamoeba | None | 6.3 | 188 | 2 | 20/200 | 1 | 0.1 | Yes | 20 | N/A | N/A | 20/80 |
| 11 | 17 | F | CL | Acanthamoeba | 3.5 | 11.6 | 290 | 6 | 20/2000 | 2 | 0.1 | Yes | 90 | N/A | N/A | 20/80 |
| 12 | 68 | F | OCP/CL | Curvularia | None | 12 | No data | 4 | LP | 2 | 0.2 | Yes | 60 | CE+ IOL | N/A | 20/50 |
| 13 | 51 | M | CL | Pseudomonas | 81 | 81 | No data | 3 | HM | 1 | 0.1 | Yes | 30 | No data | No data | No data |
| 14 | 44 | M | CK | Acanthamoeba Candida, MRSA | 16.2 | 9 | No data | 16 | HM | 1 | 0.2 | No | Not resolved | TPK | Edema, neovascularization | HM |
| 15 | 27 | F | CL | Acanthamoeba | 36 | 36 | 229 | 8 | LP | 1 | 0.2 | No | Not resolved | TPK | Edema, Descemet folds | 20/20 |
| 16 | 40 | F | CL | Acanthamoeba | 25 | 2 | 300 | 24 | HM | 2 | 0.2 | No | Not resolved | TPK | Edema, Descemet folds | 20/80 |
| 17 | 56 | M | Soil | Fusarium | 9.6 | 81 | 252 | 2 | LP | 1 | 0.1 | No | Not resolved | TPK | Eviscerated | NLP |
| 18 | 66 | M | None | Fusarium | 81 | 36 | 243 | 4 | LP | 1 | 0.1 | No | Not resolved | TKP | Edema | HM |
*
M= male, F= female, CK= chemical keratitis, OCP= Ocular cicatricial pemphigoid, CL= contact lens, BCVA= best corrected visual acuity, SMT = standard medical treatment, PKP= Penetrating keratoplasty, TPK= therapeutic penetrating keratoplasty, CE+IOL= cataract extraction + intraocular lens placement, HM: hand motion, LP: Light perception