Table 1.
Effect of exogenous melatonin in diabetic rat model with respect to the weekly blood glucose level and serum random sugar level in different experimental groups.
| Groups | Weekly changes in blood glucose level (mg/dl) |
Week-IV | Random sugar level in serum (mg/dl) | |||
|---|---|---|---|---|---|---|
| Before induction | Week-I | Week-II | Week-III | |||
| CONT | 130 ± 7 | 126 ± 6 | 128 ± 8 | 132 ± 3 | 1130 ± 6 | 64.18 ± 3.29 |
| STZ | 127 ± 10 | 380 ± 7∗∗ | 386 ± 14∗∗∗ | 360 ± 9∗∗∗ | 367 ± 10∗∗ | 97.675.80∗∗ |
| STZ + MEL | 124 ± 8 | 408 ± 9∗ | 398 ± 12∗∗ | 290 ± 10∗ | 221 ± 12∗ | 75.68 ± 5.97∗ |
| MEL | 128 ± 12 | 134 ± 4 | 130 ± 16 | 128 ± 8 | 125 ± 11 | 67.17 ± 4.37 |
| STZ + GB | 129 ± 4 | 412 ± 8∗ | 370 ± 7∗ | 280 ± 15∗ | 232 ± 9∗ | 78.0 ± 5.0∗ |
| GB | 134 ± 5 | 130 ± 9 | 140 ± 9 | 125 ± 5 | 125 ± 6 | 69.34 ± 69.34 |
@F Value = 6.512.
Data are mean ± S.E.; N = 6.
Abbreviations: CONT = Control; STZ = Streptozotocin; MEL = Melatonin; GB = Glibenclamide.
@ Significant at 5% for ANOVA.
STZ vs CONT.
STZ vs STZ + MEL.
STZ vs STZ + GB.
Superscripts denotes; ∗ = 0.05; ∗∗ = 0.01 and ∗∗∗ = 0.001.