Table 2.
Percent protective effect of exogenous melatonin in an STZ induced diabetic rat model with respect to the different hepatic biochemical parameters.
| Groups | Glycogen (μg/mg of tissue) |
GSH Cycle (Unit/min/mg protein) |
GST Unit/min/mg protein |
Protein content (μg/mg) | ||
|---|---|---|---|---|---|---|
| GR | GPX | G6PDH | ||||
| CONT | 2773.29 ± 214.3 | 47.07 ± 2.8 | 598.14 ± 32.4 | 37.52 ± 4.7 | 598.14 ± 32.4 | 35.23 ± 2.2 |
| STZ | 1441.19 ± 128.9∗∗∗ | 32.09 ± 2.8∗∗ | 357.19 ± 32.2 | 19.57 ± 2.5∗∗ | 357.19 ± 32.2∗∗ | 14.82 ± 1.6∗∗∗ |
| STZ + MEL | 2256.47 ± 82.8∗ | 44.57 ± 4.4∗ | 501.67 ± 15.8 | 33.89 ± 3.4∗ | 501.67 ± 15.2∗ | 31.5 ± 1.9∗∗ |
| %Protection by MEL | 61.10% | 67.62% | 65.65% | 79.75% | 62.08% | 81.64% |
| MEL | 2674.69 ± 261.4 | 49.09 ± 3.5 | 611.92 ± 22.6 | 38.77 ± 4.3 | 611.92 ± 22.6 | 35.05 ± 2.4 |
| STZ + GB | 2091.69 ± 174.7∗ | 35.84 ± 2.8∗ | 497.46 ± 25.5 | 32.17 ± 2.7∗ | 497.46 ± 25.5∗ | 27.75 ± 2.6∗∗ |
| %Protection by GB | 48.75% | 25.02% | 36.83% | 70.60% | 60.08% | 61.78% |
| GB | 2598.88 ± 199.7 | 48.7 ± 4.3 | 578.22 ± 52.5 | 36.84 ± 4.7 | 578.22 ± 52.5 | 34.15 ± 2.3 |
| @F Value | 8.556 | 5.369 | 7.327 | 4.179 | 10.144 | 16.081 |
Data are mean ± S.E.; N = 6.
Abbreviations: CONT = Control; STZ = Streptozotocin; MEL = Melatonin; GB = Glibenclamide; GR = Glutathione Reductase; GPx = Glutathione Peroxidase; G6PDH = Glucose-6-Phosphate Dehydrogenase and GST = Glutathione-S-Transferase.
@ Significant at 5% for ANOVA.
STZ vs CONT.
STZ vs STZ + MEL.
STZ vs STZ + GB.
Superscripts denotes; ∗ = 0.05; ∗∗ = 0.01, ∗∗∗ = 0.001.