Table 3.
Percent protective effect of exogenous melatonin in diabetic rat model with respect to the on different renal cortex biochemical parameters.
| Groups | Glycogen (μg/mg of tissue) |
GSH Cycle (unit/min/mg protein) |
GST unit/min/mg protein |
Total protein content (μg/mg) | ||
|---|---|---|---|---|---|---|
| GR | GPX | G6PDH | ||||
| CONT | 2243.72 ± 145.66 | 45.9 ± 4.61 | 7.21 ± 0.54 | 39.09 ± 3.12 | 579.62 ± 56.84 | 32.04 ± 1.91 |
| STZ | 1075.92 ± 100.83∗∗∗ | 26.17 ± 2.07∗∗ | 3.2 ± 0.30∗∗∗ | 18.4 ± 2.01∗∗ | 314 ± 56.98∗∗∗ | 15.25 ± 1.87∗∗∗ |
| STZ + MEL | 1935.65 ± 128.96∗ | 43 ± 4.57∗ | 6.19 ± 0.38∗ | 36.09 ± 2.47∗ | 557.91 ± 23.69∗∗ | 28.02 ± 2.71∗∗ |
| %Protection by MEL | 68.86% | 85.30% | 74.35% | 85.75% | 91.76% | 76.07% |
| MEL | 2225.46 ± 236.49 | 45.4 ± 5.03 | 7.19 ± 0.75 | 45.87 ± 4.06 | 534.79 ± 40.84 | 33.94 ± 2.08 |
| STZ + GB | 1901.77 ± 66.44∗ | 39.69 ± 3.10∗ | 5.60 ± 0.50∗ | 33.04 ± 3.47∗ | 528.79 ± 39.25∗∗ | 28.61 ± 1.82∗ |
| %Protection by GB | 70.72% | 26.17% | 59.84% | 69.42% | 80.08% | 81.61% |
| GB | 2230.59 ± 168.79 | 45.71 ± 3.40 | 7.75 ± 0.55 | 34.75 ± 4.74 | 560.7 ± 18.66 | 32.37 ± 3.03 |
| @F Value | 10.588 | 4.516 | 8.514 | 7.148 | 6.666 | 8.326 |
Data are mean ± S.E.; N = 6.
Abbreviations: CONT = Control; STZ = Streptozotocin; MEL = Melatonin; GB = Glibenclamide; GR = Glutathione Reductase.
GPX = Glutathione Peroxidase; G6PDH = Glucose-6-Phosphate Dehydrogenase and GST = Glutathione-S-Transferase.
@ Significant at 5% for ANOVA.
STZ vs CONT.
STZ vs STZ + MEL.
STZ vs STZ + GB.
Superscripts denotes; ∗ = 0.05; ∗∗ = 0.01, ∗∗∗ = 0.001.