Table 4.
Percent protective effect of exogenous melatonin in diabetic rat model with respect to the serum biochemistry of diabetic.
| Groups | Electrolytes (mmol/L) |
Serum proteins (g/dl) |
Bilirubin (mg/dl) |
Insulin (ng/ml) | |||
|---|---|---|---|---|---|---|---|
| Sodium (Na+) | Potassium (K+) | Total protein | Albumins | Globulins | |||
| CONT | 116.34 ± 2.78 | 2.79 ± 0.38 | 7.89 ± 0.53 | 4.37 ± 0.18 | 3.5 ± 0.32 | 0.25 ± 0.02 | 1.58 ± 0.11 |
| STZ | 137.17 ± 3.17∗∗∗ | 4.5 ± 0.35∗ | 3.95 ± 0.67∗∗ | 2.55 ± 0.48∗∗ | 1.40 ± 0.41∗∗∗ | 0.717 ± 0.05∗∗∗ | 0.59 ± 0.08∗∗∗ |
| STZ + MEL | 122.67 ± 2.31∗∗ | 2.79 ± 0.29∗ | 6.745 ± 0.52∗ | 3.92 ± 0.29∗ | 2.84 ± 0.20∗∗ | 0.445 ± 0.09∗∗ | 0.99 ± 0.10∗∗ |
| %Protection by MEL | 69.61% | 99.70% | 71.05% | 81.40% | 66.74% | 58.20% | 41.71% |
| MEL | 118.84 ± 2.14 | 2.85 ± 0.17 | 7.52 ± 0.57 | 2.30 ± 0.33 | 3.45 ± 0.26 | 0.325 ± 0.05 | 1.50±±0.03 |
| STZ + GB | 123 ± 4.35∗∗ | 3.5 ± 0.28∗ | 6.48 ± 0.53∗ | 3.80 ± 0.25∗ | 2.66 ± 0.16∗ | 0.5134 ± 0.05∗∗ | 0.83 ± 0.04∗ |
| %Protection by GB | 87.99% | 58.13% | 64.07% | 77.27 | 58.31% | 43.56% | 24.08% |
| GB | 119.34 ± 2.59 | 2.9 ± 0.25 | 7.45 ± 0.72 | 3.97 ± 0.30 | 3.49 ± 0.37 | 0.354 ± 0.03 | 1.46 ± 0.12 |
| @ F Value | 2.45 | 6.41 | 6.966 | 8.888 | 8.775 | 6.484 | 23.407 |
Data are mean ± S.E.; N = 6.
Abbreviations: CONT = Control; STZ = Streptozotocin; MEL = Melatonin; GB = Glibenclamide.
@ Significant at 5% for ANOVA.
STZ vs CONT.
STZ vs STZ + MEL.
STZ vs STZ + GB.
Superscripts denotes; ∗ = 0.05; ∗∗ = 0.01, ∗∗∗ = 0.001.