Table 6.
Percent protective effect of exogenous melatonin in diabetic rat model with respect to the on different white blood cell indices.
| Groups | RDW (%) | PDW (%) | Platelets (x 103/μl) | Leukocytes (/Cmm) | Polymorphs (%) |
|---|---|---|---|---|---|
| CONT | 23.04 ± 1.58 | 26.04 ± 1.54 | 88.34 ± 3.34 | 20222 ± 1046.12 | 71.4 ± 1.42 |
| STZ | 13.03 ± 1.57∗∗∗ | 22.99 ± 1.37∗∗ | 71 ± 3.42∗ | 11858.33 ± 292.12∗∗∗ | 43.36 ± 1.72∗∗∗ |
| STZ + MEL | 19.44 ± 0.72∗∗ | 23.32 ± 1.78∗ | 87.333 ± 3.03∗ | 13983 ± 858.25∗∗ | 67.98 ± 1.51∗∗ |
| % Protection by MEL | 64.03% | 13.44% | 106.1% | 74.5% | 87.80% |
| MEL | 21.59 ± 1.46 | 26.34 ± 1.66 | 89.33 ± 4.22 | 14345 ± 1309.75 | 70.61 ± 3.00 |
| STZ + GB | 17.767 ± 1.63NS | 23.4 ± 1.22∗ | 87.83 ± 3.43∗ | 11053 ± 882.86∗∗ | 67.61 ± 1.69∗∗ |
| % Protection by GB | 47.32% | 10.81% | 118.34% | 70.26% | 61.51% |
| GB | 21.3 ± 0.86 | 24.3 ± 1.26 | 90.34 ± 4.00 | 12175 ± 1102.01 | 68.3 ± 1.45 |
| @ F Value | 8.476 | 1.152 | 0.233 | 14.184 | 38.480 |
Data are mean ± S.E.; N = 6.
Abbreviations: CONT = Control; STZ = Streptozotocin; MEL = Melatonin; GB = Glibenclamide; RDW = Red Blood Cell Distribution Width.
PDW = Platelet Distribution Width.
@ Significant at 5% for ANOVA.
STZ vs CONT.
STZ vs STZ + MEL.
STZ vs STZ + GB.
Superscripts denotes; ∗ = 0.05, ∗∗ = 0.01, ∗∗∗ = 0.001.