Skip to main content
. 2020 Apr 10;63(8):4047–4068. doi: 10.1021/acs.jmedchem.9b02076

Figure 4.

Figure 4

Binding mode of 25b and 23d. Panels A and B show two different views of the binding mode of 25b (PDB code 6TON). Panels C and D show two views of the binding mode of 23d (PDB code 6TOK). The panels show the changed conformation of Arg28 and the new interaction with one of the compound’s pyrazole nitrogen atoms. In all panels, the surface of the BCL6 BTB dimer is shown as a gray transparent surface, with the two individual monomers displayed as ribbons and colored in gray and cyan. Key residues are shown as lines. Compounds are shown as orange ball and sticks, selected water molecules as red spheres, and H-bonds as yellow dashed lines.