Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(Left) Total SCID mouse blood concentrations of 1 (CCT369260) after po dosing at 5 (blue triangles), 15 (red circles), and 50 (green squares) mg/kg vs predicted active concentration (dashed line). (Right) Data for individual animals showing cmax, tmax, and total AUC10h in SCID mouse at 5, 15, and 50 mg/kg doses. All experiments were carried out according to the U.K. guidelines for animal experimentation.
