Skip to main content
. 2020 Apr 10;63(8):4047–4068. doi: 10.1021/acs.jmedchem.9b02076

Scheme 3. Synthesis of Compounds from Table 3, Investigating Different Substitution Patterns on Pyrimidine or Pyridine Rings.

Scheme 3

Reagents and conditions: (a) heteroaryl chloride, DIPEA, NMP or DMF, 80–120 °C, 30 min; (b) 4-bromo- or iodopyridine, Xantphos, Pd2(dba)3, cesium carbonate, NMP/toluene, 140 °C, 1 h.