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. 2020 Apr 10;63(8):4047–4068. doi: 10.1021/acs.jmedchem.9b02076

Table 1. Potency and Solubility Data for Hit and Early Lead Compounds.

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a

Data represent the geometric mean. See Supporting Information Table S1 for full statistics. Potency was later confirmed in the TR-FRET assay described in the manuscript; see Supporting Information Table S2.

b

Kinetic solubility measured by NMR in HEPES buffer (containing 5% DMSO) at pH 8. LE calculated as 1.4 × pIC50/HAC.