Table 5. Modifications to the Pyrimidine 2-Substituent.

^aData represent the geometric mean of at least three replicates. See Supporting Information Table S2 for full statistics.

^bKinetic solubility measured by NMR in HEPES buffer and 5% DMSO at pH 8, and/or where data are shown in brackets, by HPLC in PBS buffer and 1% DMSO at pH 7.4. ^#These compounds showed <25% degradation of BCL6 in single concentration experiments at 10 μM. n.d. = not done.