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. 2020 Apr 27;10:7078. doi: 10.1038/s41598-020-63796-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of different treatments on tumor (non–small cell lung carcinoma) size and on tumor necrosis in patient-derived xenograft PDX4 in NSG mice. (A) Tumor growth curves are expressed as a percentage of the change of initial tumor volume, which was considered as 100%. Each point represents a measurement day given as the mean ± SEM of the tumor volume of the mice of each group (2 tumors per mice, i.e., n = 8 tumors per group). (B) Mice were sacrificed after six weeks and the tumor volume was measured. Results are shown as mean ± SEM of the tumor volume of the mice of each group (n = 8 tumors per group). Statistical significance is indicated (p ≤ 0.05) and was analyzed by the Kruskal-Wallis non-parametric test. Post hoc between-group comparisons were made with the Mann-Whitney test. (C) The necrosis index is expressed as a percentage of tumor necrotic areas (n = 6–8 tumors per group). Values represent the percentage (mean ± SEM). Statistical significance is indicated (p ≤ 0.05) and was analyzed by the Kruskal-Wallis non-parametric test. Post hoc between-group comparisons were made with the Mann-Whitney test.