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. 2020 Apr 27;10:7078. doi: 10.1038/s41598-020-63796-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor PDX histologies and inflammatory response associated with tumor regression in response to anti-PD-1 treatments in ‘responder’ (PDX4, A) and ‘non-responder’ tumors (PDX6, B). (1) PDX4 tumor treated with anti-PD-1 stained with H&E (×2). (2) Amplified image of the area inside the square in (1), where necrotic areas with inflammatory cell – mainly neutrophils – infiltrates can be seen (x100). (3) PDX6 tumor treated with anti-PD-1 stained with H&E, where necrotic areas and viable tumor areas are indicated (×2). (4) Amplified image of the area inside the square in (3), where necrotic areas without inflammatory infiltrates (no neutrophils) can be seen (x100).