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. 2020 Apr 27;10:7052. doi: 10.1038/s41598-020-64017-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Elastase activity assay shows retained AAT protease inhibition and protein function. (a) Elastase activity was measured in n = 14 cases. A majority of cases display a decreased elastase activity when incubated with conditioned media from cell cultures. (b) Median elastase activity of all cases showed a robust inhibition of elastase activity in the presence of conditioned media displaying similar kinetics as control elastase inhibitor. (c) End-point (60 minutes) analysis showed significant (Wilcoxon matched-pairs signed rank test) decrease in elastase activity in conditioned media from cells treated with AAT modified mRNA.