Table 3.

Factor analysis of DEP gene signature in pre-malignant adjacent breast tissues among postmenopausal women revealed 7 latent factors.

Factor	Genes loading onto factor
Factor 1	FOXA1,AR,KRT19,TMEM50B,CBLC,TMEM30B,KRT18,PRSS8,WFDC2,ST6GALNAC2,MUC1,NAT8L,TGFB3,FAM134B,ICA1,HMGCS2,TFAP2B
Factor 2	P4HA1,RNF180,MPZL3,TMC4,TMEM47,PRLR,PLEKHA6,ACAA2,TOM1L1,GALNT3, CA8,AADAT,AP1M2,MBOAT1,SLC44A3,CXADR,TNFRSF21,TLR2,AREG,ABCG2
Factor 3	RPS16,FXYD3,CD59,XBP1,SPINT2,IRX3,QSOX1,PTGDS,SLC5A3,TACSTD2,SH3YL1,CRABP2,MAL2
Factor 4	LCN2,SERPINB5,ANXA8L1,PLEKHB1,SLC34A2,PROM1,C4ORF19,CLDN8,SPINT1
Factor 5	SECTM1,CD14,PLIN2,CPVL,CD24,ALDOC,ANGPTL4,PPAP2C,ABHD14B
Factor 6	AQP5,FOLR1,EPCAM,KCNK1,PDZK1IP1,CLDN3,RAB25,ESRP1,FRK,SLC12A2
Factor 7	TSPAN1,SLC44A4,F13A1
No factor assignment	ASPN,CMTM8,PLA2G2A,TMEM184A

Genes in bold are those that were significant at p < 0.05 from univariate analysis (Fig. 3), many of which load onto factor 2.