Table 4.
Transcription factor enrichment analysis of genes in factor #2 using ChIP-X Enrichment Analysis (ChEA) database via EnrichR.
| Transcription Factor | Contexta | Species | P-valueb | Adjusted P-value |
|---|---|---|---|---|
| SOX2 | SW620 | Human | 0.000 | 0.187 |
| AR | LNCAP | Human | 0.003 | 0.340 |
| SOX2 | STOMACH | Mouse | 0.011 | 0.519 |
| FOXA1 | ENDOMETRIOID-ADENOCARCINOMA | Human | 0.020 | 0.564 |
| GATA1 | MEL | Mouse | 0.031 | 0.623 |
| AR | VCAP | Human | 0.036 | 0.623 |
| TBX20 | HEART | Mouse | 0.043 | 0.623 |
| TBX20 | HEART | Mouse | 0.043 | 0.623 |
| GATA1 | MEL86 | Mouse | 0.043 | 0.623 |
| FOXA1 | PDAC | Human | 0.043 | 0.623 |
aRefers to cell-line or tissue in which the experiment was done.
bThe p-value is computed from a Fisher’s exact test (FET), a proportion test that assumes a binomial distribution and independence for probability of any gene belonging to any gene-set.
The top 5 transcription factors that appeared at least twice with a p-value < 0.05 are shown. ChEA is a gene-set enrichment analysis tool that tests if query gene-sets are enriched with genes that are putative targets of transcription factors, utilizing a gene-set library of transcription factors and their putative target genes curated from published ChIP-chip, ChIP-seq, and similar experiments (Lachmann et al. 2010).