Table 2.
AAV Neutralizing Factor Titer in the Serum and CSF
| Serum NF Titer |
CSF NF Titer |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Animal Identification | Route | Capsid | Baseline | d0 | d3 | d7 | d10 | dEuth | d0 | dEuth |
| Mac 1 | LIT-KT | 10 | <1/10 | <1/10 | NA | NA | NA | 1/10,000 | <1/10 | <1/10 |
| Mac 2 | LIT-KT | 10 | <1/10 | NA | <1/10 | NA | 1/10,000 | 1/1,000 | <1/10 | <1/10 |
| Mac 3 | LIT-KT | 9 | NA | NA | <1/10 | 1/1,000 | 1/1,000 | 1/10,000 | NA | 1/100 |
| Mac 4 | LIT-KT | 9 | <1/10 | NA | NA | 1/10,000 | 1/10,000 | 1/10,000 | <1/10 | 1/100 |
| Mac 5 | LIT-KT | 9 | NA | NA | <1/10 | 1/1,000 | 1/1,000 | 1/1,000 | <1/10 | <1/10 |
| Mac 6 | LIT-KT | 9 | 1/100 | NA | <1/10 | <1/10 | 1/1,000 | 1/1,000 | <1/10 | <1/10 |
| Mac 7 | ICV | 9 | <1/10 | NA | <1/10 | 1/1,000 | 1/1,000 | 1/1,000 | NA | 1/100 |
| Mac 8 | ICV | 9 | <1/10 | NA | <1/10 | 1/1,000 | 1/1,000 | 1/1,000 | <1/10 | <1/10 |
NF, neutralizing factor; CSF, cerebrospinal fluid; d, day; dEuth, day of euthanasia; NA, not available sample.