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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Periodontal Res. 2019 Sep 25;55(1):107–115. doi: 10.1111/jre.12694

Figure 4:

Figure 4:

Visualization of native collagen fiber morphology by second harmonic generation (SHG) in PDL treated with inhibitors of TG activity in 5D ligature mice. SHG orthogonal volume images generated from z-stacks taken at 0.2μm/slice for depths of up to 60μm of native PDL +/− DMSO/BPA injections following 5-day ligature treatment. Apparent increases in collagen fiber morphology and organization are observable in BPA-treated PDL (panels C & D) versus those treated with DMSO (A and B). The appearance of thick collagen fiber bundles is apparent in 5D BPA-treated PDL (D) versus vehicle only (B). Arrows, collagen fiber bundles. Scale bar = 20μm.