Table 1.
Cross-reference with GLGC to prioritize 54 genes.
| Human Association | Gene Symbol | Mouse Replication NO. (transcript : protein: both) | Human GWAS Lipid Traits (*sub-threshold) | Lipid and Cholesterol Metabolism Relevant Pathways |
|---|---|---|---|---|
| Genome-wide | Fads1 | 3 ; - ; - | TC, LDL, HDL, TG | Fatty acid and triacylglycerol metabolism |
| Fads2 | 3 ; - ; - | TC, LDL, HDL, TG | Fatty acid metabolism | |
| Acsl5 | 3 ; - ; - | TC, LDL, HDL, TG | Fatty acid metabolism | |
| Gpam | 3 ; - ; - | TC, LDL, HDL, TG | Metabolism of lipids and lipoproteins | |
| Hmgcr | 6 ; 3 ; 2 | TC, LDL | Cholesterol Biosynthesis | |
| Ldlr | 6 ; - ; - | TC, LDL, HDL | Plasma lipoprotein clearance | |
| Mmab | 8 ; 2 ; 2 | TC, HDL | Transcript adjacent to Mvk | |
| Mvk | 7 ; 3 ; 2 | TC, HDL | Cholesterol biosynthesis | |
| Acacb | 3 ; - ; - | TC, HDL | Fatty Acid Biosynthesis | |
| Pcsk9 | 4 ; - ; - | TC, LDL | Plasma lipoprotein clearance | |
| Dhcr24 | 3 ; - ; 2 | TC, LDL | Cholesterol biosynthesis | |
| Echdc1 | 5 ; - ; - | HDL, TG | Fatty Acid Biosynthesis | |
| Aacs | 3; - ; - | TC*, HDL, TG | Fatty acid and triacylglycerol metabolism | |
| Fdft1 | 8 ; 3 ; 2 | TG | Cholesterol biosynthesis | |
| Sub-Threshold | Samm50 | 3 ; - ; - | TC* | Transcript adjacent to Pnpla3 |
| Mvd | 8 ; 3 ; 2 | LDL* | Cholesterol Biosynthesis | |
| Sqle | 8 ; 3 ; 2 | TG* | Cholesterol Biosynthesis | |
| Cyp2r1 | 3 ; - ; - | HDL* | Fatty Acid Biosynthesis | |
| Tmem97 | 5 ; - ; 2 | TC*, LDL* | Cholesterol Regulation | |
| Abcb4 | - ; - ; 2 | LDL* | Fatty acid and triacylglycerol metabolism | |
| Fdps | 8 ; 3 ; 2 | TC*, LDL* | Cholesterol Biosynthesis | |
| Acly | 3 ; - ; 0 | TC*, LDL*, HDL* | Fatty Acid Biosynthesis | |
| Acss2 | 7 ; - ; 2 | TC*, HDL*, TG* | Fatty Acid Biosynthesis | |
| Thrsp | 3 ; - ; - | TC*, LDL* | Fatty acid and triacylglycerol metabolism | |
| Acat2 | 7 ; - ; - | TC*, LDL* | Cholesterol biosynthesis | |
| Tm7sf2 | 5 ; 2 ; 2 | TC*, LDL*, HDL* | Cholesterol biosynthesis | |
| Insig1 | 4 ; - ; - | TC* | Regulation of cholesterol biosynthesis | |
| X -chromosome | Nsdhl | 8 ; 3 ; 2 | Cholesterol Biosynthesis | |
| Ebp | 3 ; - ; - | Cholesterol Biosynthesis | ||
| Genome-wide | Lrpap1 | - ; - ; 2 | TC, LDL, TG | |
| Prss8 | 4 ; - ; - | TC*, LDL*, TG | ||
| Hdgf | 3 ; - ; - | HDL | ||
| Ptprj | 3 ; - ; - | TC, HDL | ||
| Sub-Threshold | Bcap29 | - ; 2 ; - | LDL*, HDL* | |
| Utp18 | - ; - ; 2 | TC*, LDL* | ||
| Sesn1 | 4 ; - ; - | TC*, LDL*, HDL* | ||
| Nol9 | - ; - ; 2 | LDL* | ||
| Aldoc | 3 ; 2 ; 2 | TC*, LDL* | ||
| Cnp | - ; - ; 2 | TC*, LDL*, HDL* | ||
| Nudt2 | 3 ; - ; - | TG* | ||
| Scpep1 | 4 ; - ; - | TG* | ||
| Gramd3 | 4 ; - ; - | TC* | ||
| Pold2 | 5 ; - ; - | TG* | ||
| Naglu | - ; - ; 2 | TC*, LDL*, HDL* | ||
| Rras | 3 ; - ; - | TC*, TG* | ||
| Tlcd1 | 4 ; - ; - | TC*, LDL* | ||
| Pgd | 3 ; - ; - | TC* | ||
| Napa | 3 ; - ; - | TC*, LDL*, HDL* | ||
| Anxa6 | 3 ; - ; - | TC* | ||
| Sigmar1 | 3 ; - ; - | TC* | ||
| X -chromosome | Cetn2 | 4 ; - ; - | ||
| Mospd2 | - ; - ; 2 | |||
| Haus7 | 5 ; - ; 2 | |||
| Slc16a2 | - ; - ; 2 |
Replicated genes were cross-referenced with human Global Lipids Genetics Consortium (GLGC) dataset to prioritize 48 genome-wide or sub-threshold significant genes and six X-chromosome genes.
TC: total cholesterol; LDL: low density lipoprotein; HDL: high density lipoprotein; TG: triglyceride.