Fig. 2.

Skeletal muscle wet weight (normalized to tibia length) and cross-sectional area for soleus and tibialis anterior (TA). Muscle wet weight for the TA (a) and soleus (b) is significantly increased in both knockout animals (MuRF1KO and MuRF2KO) when compared to C57BL/6 mice. Administration of monocrotaline (MCT) to the animals resulted in a reduced muscle wet weight of the TA (c) and soleus muscle (d) in the C57BL/6 animals, whereas MCT had no effect on muscle wet weight in the MuRF1KO and MuRF2KO animals (c, d). In addition, also the cross-sectional area (CSA) of TA (e) and soleus (f) was reduced in C57BL/6 whereas this reduction was not seen in MuRF1KO and MuRF2KO mice. Data are presented as mean ± SEM