Fig. 3.

In vitro skeletal muscle function of the soleus muscle determined in C57BL/6 (a, b), MuRF1KO (c, d), and MuRF2KO (e, f) animals. Muscle force is shown as absolute force (a, c, e) and as specific force (b, d, f). Monocrotaline significantly impaired absolute muscle force only in C57BL6 animals (a) but not in MuRF1KO (c) and MuRF2KO mice (e). Monocrotaline had no effect on muscle specific force. Data are presented as mean ± SEM. Control animals are depicted in black squares and solid line whereas MCT-treated animals are shown in triangles and dotted lines