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. 2020 Apr 27;11(4):291. doi: 10.1038/s41419-020-2488-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Natural antioxidants extracted from plants exert antioxidative effects mainly through the following pathways: 1. direct clearing of ROS; 2. chelating ferric ions to inhibit ROS production; 3. improving the activities of anti-oxidases such as SOD and CAT; 4. promoting SOD mRNA expressions; 5. clearing ROS by activating the Nrf2 antioxidative pathway.