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. 2020 Apr 27;10:7058. doi: 10.1038/s41598-020-63996-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DHR treatment represses ECM remodeling and cytokine expression of CAFs. (a–b) Collagen gel remodeling capacity of SCAF#36 cells treated with 0.1 μM or 1 μM DHR for three days. (a) Representative images of collagen gel contraction. (b) Gel size is expressed as a percentage of the initial size. Similar results were observed in independent experiments. (c) Pro-inflammatory gene signatures of DHR-treated SCAF#36 cells. mRNA was isolated from SCAF#36 cells treated with 0.1 μM or 1 μM DHR for three days, and pro-inflammatory gene expression was normalized to 18 s rRNA levels. Experiments were done in triplicate. Bars represent the means ± SEM of six independent experiments. Differences were evaluated by two-tailed student’s t-test. ***P < 0.005.