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. 2020 Apr 27;11:2049. doi: 10.1038/s41467-020-15695-x

Fig. 5. Mechanism driving HLA-DR and co-stimulatory molecule upregulation on PB ILCs after IL-1β or IL-18 treatment.

Fig. 5

a, b Flow cytometric analysis of STAT1Tyr701, STAT1Ser727, and NF-κB-p65Ser529 phosphorylation in sorted PB ILC3-like cells (a) and ILC2 (b) following 10, 30, or 60 min incubation with IL-2, IL-2 plus IL-1β, or IL-2 plus IL-18. Representative example of five independent experiments is displayed. c MFI of HLA-DR, CD70, CD80, and CD86 expression on sorted PB ILC3-like cells, following 72 h incubation with IL-2, IL-2 plus IL-1β, or IL-2 plus IL-1β in the presence BAY11-7082. N (donors) = 7 for HLA-DR, 8 for CD70 and CD86 and 5 for CD80; bars and error bars indicate mean and SEM; statistical significance was assessed using two-sided Wilcoxon matched-pairs signed rank test. Source data are provided as a source data file.