Table 2.

Functional annotation cluster analysis of unique protein identities from neutravidin‐treated samples and biotinylated nonredundant proteins detected by MS

Biological process	Gene count	p‐Value	Genes	Fold change	FDR
Annotation cluster 1. Enrichment score: 2.33
MAPK signaling pathway	8	1.2 × 10−6	MAPK14, MAPK3, MAP2K4, MAP3K7, HSPA6, MAP4K4, RELA, TAB2	12.0	1.3 × 10−3
Epstein–Barr virus infection	6	8.4 × 10−6	RELA, PSMD6, MAP2K4, MAP3K7, TAB2, MAPK14	18.8	9.1 × 10−3
Toll‐like receptor pathway	5	7.5 × 10−5	RELA, MAP2K4, MAP3K7, TAB2, MAPK14	17.8	7.7 × 10−2
Annotation cluster 2. Enrichment score: 1.17
Transcription regulation	11	1.7 × 10−3	MAPK14, ARGLU1, NRBF2, MTA1, TEAD1, ILF3, MAP3K7, CHAF1B, RELA, ZNF771, TAB2	2.8	1.7
Transcription	10	2.0 × 10−2	CHAF1B, RELA, NRBF2, ARGLU1, ANF771, ILF3, MAP3K7, MAPK14, TEAD1, MTA1	2.3	2.0
Annotation cluster 3. Enrichment score: 0.95
ZnF‐associated	8	3.7 × 10−2	XPA, ZNF771, TAB2, EGLN1, MTA1, RBM27, ZC3H11A, ZC3H15	2.4	2.4

Note: Top 3 DAVID DB annotation clusters (n = 37 proteins from three biological replicates). Fold change refers to enrichment in comparison to the whole human proteome.

Abbreviations: FDR, false discovery rate; MS, mass spectrometry; ZnF, zinc finger.