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. Author manuscript; available in PMC: 2020 Apr 27.
Published in final edited form as: Nat Med. 2019 Nov;25(11):1796. doi: 10.1038/s41591-019-0637-6

CCR5-Δ32 is deleterious in the homozygous state in humans

Xinzhu Wei, Rasmus Nielsen
PMCID: PMC7184837  NIHMSID: NIHMS1581094  PMID: 31595084

The authors are retracting this Brief Communication to correct the scientific literature. Arising from exchanges with David Reich and colleagues, they have been made aware of a genotyping calling bias in the underlying UK Biobank data from which the main results of the study were drawn. Further analyses confirmed that the central finding of the study – that homozygous CCR5-Δ32 mutation is associated with increased mortality in the UK Biobank – is a result of this technical artifact. Because the main conclusion of the paper is invalid, both authors, Xinzhu Wei and Rasmus Nielsen, wish and agree to retract the Brief Communication in its entirety.

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