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How can an impaired sodium homeostasis of cardiac myocytes lead to arrhythmias? AP, action potential; NHE, Na+/H+ exchanger; [Na+]i, intracellular sodium concentration; NCX, Na+/Ca2+ exchanger; [Ca2+]i, intracellular calcium concentration; SR, sarcoplasmic reticulum; CaMKII, calcium/calmodulin dependent protein kinase II.
