Table 2.
Significantly Enriched Reactome Pathways Among the 1950 Genes Significantly Overexpressed in the Lung B Cells Relative to the Spleen B Cells
| Pathway Description | Number of Overexpressed Genes | Total Number of Genes | FDR-Adjusted P Value |
|---|---|---|---|
| mRNA Splicing | 43 | 171 | 5.7E-05 |
| Posttranslational protein modification | 201 | 1321 | 5.7E-05 |
| RAF-independent MAPK1/3 activation | 13 | 23 | 5.7E-05 |
| Processing of Capped Intron-Containing Pre-mRNA | 51 | 224 | 6.0E-05 |
| Immune System | 240 | 1649 | 6.0E-05 |
| mRNA Splicing—Major Pathway | 40 | 163 | 1.1E-04 |
| Signaling by TGF-β Receptor Complex | 21 | 60 | 1.1E-04 |
| Vesicle-mediated transport | 105 | 608 | 1.1E-04 |
| Toll-Like Receptor 4 (TLR4) Cascade | 30 | 107 | 1.1E-04 |
| Adaptive Immune System | 115 | 690 | 1.7E-04 |
| Membrane Trafficking | 99 | 573 | 1.8E-04 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 11 | 20 | 2.0E-04 |
| Golgi-Associated Vesicle Biogenesis | 18 | 51 | 3.5E-04 |
| MyD88-independent TLR4 cascade | 25 | 87 | 3.5E-04 |
| TRIF(TICAM1)-mediated TLR4 signaling | 25 | 87 | 3.5E-04 |
| trans-Golgi Network Vesicle Budding | 21 | 67 | 4.1E-04 |
| Clathrin-derived vesicle budding | 21 | 67 | 4.1E-04 |
| Negative regulation of MAPK pathway | 15 | 39 | 5.5E-04 |
| Toll-Like Receptor 10 (TLR10) Cascade | 21 | 70 | 7.2E-04 |
| Toll-Like Receptor 5 (TLR5) Cascade | 21 | 70 | 7.2E-04 |
| MyD88 cascade initiated on plasma membrane | 21 | 70 | 7.2E-04 |
| Toll-Like Receptor 7/8 (TLR7/8) Cascade | 22 | 76 | 7.2E-04 |
| MyD88-dependent cascade initiated on endosome | 22 | 76 | 7.2E-04 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 21 | 71 | 7.2E-04 |
| Toll-Like Receptor TLR1:TLR2 Cascade | 21 | 71 | 7.2E-04 |
| Toll-Like Receptor TLR6:TLR2 Cascade | 21 | 71 | 7.2E-04 |
| Toll-Like Receptor 2 (TLR2) Cascade | 21 | 71 | 7.2E-04 |
| Toll-Like Receptor 3 (TLR3) Cascade | 20 | 67 | 9.6E-04 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 14 | 38 | 1.2E-03 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 21 | 74 | 1.3E-03 |
| Toll-Like Receptor 9 (TLR9) Cascade | 22 | 80 | 1.4E-03 |
| Clathrin-mediated endocytosis | 31 | 134 | 1.6E-03 |
| Toll-Like Receptor Cascades | 33 | 147 | 1.7E-03 |
| Metabolism of proteins | 222 | 1619 | 2.3E-03 |
| MHC class II antigen presentation | 28 | 119 | 2.5E-03 |
| Innate Immune System | 139 | 948 | 3.8E-03 |
| Signaling by TGF-β family members | 22 | 87 | 4.7E-03 |
| Cleavage of Growing Transcript in the Termination Region | 17 | 59 | 4.7E-03 |
| RNA Polymerase II Transcription Termination | 17 | 59 | 4.7E-03 |
| Cargo recognition for clathrin-mediated endocytosis | 23 | 96 | 7.3E-03 |
| SUMOylation of transcription cofactors | 12 | 35 | 7.4E-03 |
Abbreviations: FDR, false discovery rate; MHC, major histocompatibility complex; mRNA, messenger ribonucleic acid; TGF, transforming growth factor.