Table 1.

Endolysosomal morpholigical and functional changes and impaired inter-organellar communications in Alzheimer’s disease (AD), HIV associated neurodegenerative disease (HAND), Parkinson’s disease (PD), and brain cancer. ND: not discussed.

Disease relevance	Endolysosome morphological changes	Endolysosome functional changes	Impaired Inter-organellar signaling	Reference
AD	+	+	ND	Cataldo et al., 2004; Cataldo et al., 2008; Chen et al., 2010; Hui et al., 2012a; Kim et al., 2016; Hui et al., 2019a
	ND	+	ND	Lee et al., 2010; Avrahami et al., 2013; Wolfe et al., 2013; Piras et al., 2016
	ND	ND	+	Area-Gomez and Schon, 2017
	+	ND	ND	Nakamura et al., 1991; Ii et al., 1993
HAND	ND	+	ND	Achim et al., 2009
	+	+	ND	Hui et al., 2012b
	+	+	ND	Chen et al., 2013; El-Hage et al., 2015
	ND	ND	+	Huang et al., 2012; Nooka and Ghorpade, 2017
	ND	+	ND	Gelman et al., 2005; Soliman et al., 2017
PD	ND	+	ND	Cuervo et al., 2004
	+	+	ND	Dehay et al., 2012
	+	+	ND	Bae et al., 2015
	ND	+	ND	Rivero-Rios et al., 2019
	+	+	+	Garcia-Sanz et al., 2017
Brain cancer	ND	+	ND	Di Cristofori et al., 2015
	+	+	+	Halcrow et al., 2019