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. 2020 Apr 1;19(6):3787–3797. doi: 10.3892/etm.2020.8632

Figure 4.

Figure 4

Effects of P-NP on the expression levels of α-actin and Mac-3 in atherosclerotic plaques of aortas. (A) Photomicrographs of cross sections of aortic roots immunohistochemically stained with α-actin. (B) Effects of P-NP on the α-actin-positive area (n=4). (C) Photomicrographs of cross-sections of aortic roots immunohistochemically stained with Mac-3. (D) Effects of P-NP on the Mac-3-positive area (n=4). Scale bar, 100 µm. ▲P<0.05 among all groups; «P<0.05 vs. control or as indicated. Mac-3, Macrophage-3; PBS, phosphate-buffered saline; NP, nanoparticle; P-IV, pitavastatin intravenous; P-NP, pitavastatin nanoparticle; P-Oral, pitavastatin oral.; SR-A1, scavenger receptor-A1; ACAT-1, cholesterol acyltransferase 1; IOD, integrated optical density.