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. 2020 Mar 25;12(7):5640–5650. doi: 10.18632/aging.102929

Figure 4.

Figure 4

Effect of PTEN on regulating the oxaliplatin sensitivity of CRC cells. (A) Transfection with siRNA-PTEN (50 pmol/ml) decreased the expression of PTEN in SW480 and HT29 cells. (B) Transfection with siRNA-PTEN (50 pmol/ml) decreased the sensitivity of SW480 and HT29 cells to oxaliplatin (10 μM) treatment. *P<0.05. (C) Transfection with plasmid-PTEN (2 μg/ml) increased the expression of PTEN in SW480/R and HT29/R cells. (D) Transfection with plasmid-PTEN (2 μg/ml) increased the sensitivity of SW480/R and HT29/R cells to oxaliplatin (10 μM) treatment. *P<0.05.