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. 2020 Apr 20;11:342. doi: 10.3389/fphys.2020.00342

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Copyright © 2020 Flores, Siques, Brito, Ordenes, Arriaza, Pena, León-Velarde, López, López de Pablo and Arribas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein expression levels in the right ventricle (RV): Ad libitum (AL) and caloric restriction (CR) groups at day 30: normoxic group (NX), chronic intermittent hypoxia group (CIH), and chronic hypoxia group (CH). (A) Activation of AMPK (p-AMPK/total AMPK ratio); (B) Activation of mTOR (p-mTOR/total mTOR ratio) normalized by β-actin; (C) PP2Cα expression levels, normalized by Ponceau staining; and (D) Representative bands are shown. Values are means (X) ± standard errors (SEs). ^∗p < 0.05: hypoxia-exposed vs. NX; ^#p < 0.05: CIH vs. CH. ^†p < 0.05: AL vs. CR.