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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: FEBS Lett. 2019 Dec 11;593(24):3583–3608. doi: 10.1002/1873-3468.13693

Fig. 6.

Fig. 6.

Cotton rat and rabbit models of adenovirus ocular infection. (A) The cotton rat model, figure adapted with permission from Tsai et al.[217] The image shown is of an adult cotton rat cornea 18 days after inoculation with HAdV-D8 (1×105 plaque-forming units). Arrows indicate subepithelial opacities observed two weeks after inoculation. (B). New Zealand White (NZW) rabbit ocular model, figure adapted with permission from Clement et al.[221] Image of Ad5-infected NZW rabbit eye at 7 days post-infection. a. Intact cornea. b. Discharge and exudates on the cornea (arrow). c. Lower eyelid inflammation/vascular dilation. d. Upper eyelid inflammation/vascular dilation. e. Prominent blood vessel (arrow) close to the caruncle of the eye. f. Corneal neovascularization. (C) Hollander rabbit corneal model, figure adapted with permission from Hauwere et al.[222] Rabbits were infected with HAdV-C5 by intracorneal and subconjunctival injections and topical instillation. The infected eye developed subepithelial opacities by day 56 post infection.