Table 2.

Transcription factors involved in regulating T cell exhaustion-specific genes.

	YY1	NFAT-AP1	NFAT1	BLIMP1	T-bet	Eomes	IRF4	BATF	FOXO1
PD1	hB↑	↓	B↑	B↓↑	B↓	-	B↑	B↑	B↑
LAG3	hB↑	↓	B	-	-	-	B	B	-
TIM3	h↑*	↓	B	-	-	-	B	B	-
IL2	hB↓	hB↑	B↓	B↓	-	-	↓	hB↓	−
IFNγ	hB↓	B↑	B↑	B↓	↑	B↑	↓	h↓	−

B indicates binds on consensus transcription factor sites present in genes.

^h denotes in humans.

↑ indicate enhances gene expression.

↓ indicate represses gene transcription.

* Indicate indirect binding.