Table 1. Frequency distribution of pfcrt, pfmdr1, pfdhps and pfdhfr SNPs in P. falciparum isolates.
| Gene | Amino
acid position |
Amino
acid a |
Kintampo | Navrongo | Accra | Total | P-value b |
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | ||||
| Pfcrt | K76T | K | 198 (93.0) | 37 (88.1) | 64 (88.9) | 299 (91.7) | 0.321 |
| T | 14 (7.0) | 5 (11.9) | 8 (11.1) | 27 (8.3) | |||
| Pfmdr1 | N86Y | N | 153 (91) | 47 (82.5) | 72 (92.3) | 272 (89.8) | 0.124 |
| Y | 15 (9.0) | 10 (17.5) | 6 (7.7) | 31 (10.2) | |||
| Y184F | Y | 64 (35.0) | 15 (27.8) | 31 (38.8) | 110 (34.9) | 0.418 | |
| F | 117(65.0) | 39 (72.2) | 49 (61.2) | 205 (65.1) | |||
| Pfdhfr | N51I | N | 38 (20.0) | 9 (16.7) | 6 (8.0) | 53 (16.6) | 0.058 |
| I | 151 (80.0) | 46 (83.3) | 69 (92.0) | 266 (83.4) | |||
| C59R | C | 15 (13.0) | 5 (16.7) | 12 (15.4) | 32 (14.1) | 0.783 | |
| R | 104 (87.0) | 25 (83.3) | 66 (84.6) | 195 (85.9) | |||
| S108N | S | 21 (11.0) | 5 (9.1) | 4 (5.1) | 30 (9.5) | 0.281 | |
| N | 163(89.0) | 50 (90.9) | 74 (94.9) | 287 (90.5) | |||
| Pfdhps | A437G | A | 23 (13.0) | 5 (9.1) | 1 (1.3) | 29 (9.4) | 0.0112 |
| G | 153 (87.0) | 50 (90.9) | 77 (98.7) | 280 (90.6) | |||
| K540E | K | 158 (99.9) | 54 (98.2 | 78 (100) | 290 (99.3) | - | |
| E | 1 (0.1) | 1 (1.8) | 0 (0) | 2 (0.7) |
aMutated amino acid depicted in bold, bP-value based on Pearson chi-Square test or Exact chi-square test for categorical variables.