Table 1. The prevalence of pfcrt, pfmdr1, pfdhps and pfdhfr mutant allelles in P. falciparum isolates.
| Gene | Amino acid
a
Position |
Amino
Acid b |
Kintampo
(2012-2013) n (%) |
Navrongo
(2012-2013) n (%) |
Accra
(2016-2017) n (%) |
Kintampo
(2016-2017) n (%) |
Total
c
n (%) |
P-value d |
|---|---|---|---|---|---|---|---|---|
| Pfcrt | K76T | K | 148 (86.3) | 37 (88.1) | 64 (88.9) | 50 (98.0) | 299
(91.7) |
0.243 |
| T | 13 (13.7) | 5 (11.9) | 8 (11.1) | 1 (2.0) | 27
(8.3) |
|||
| Pfmdr1 | N86Y | N | 103 (89.6) | 47 (82.5) | 72 (92.3) | 50 (94.3) | 272
(89.8) |
0.166 |
| Y | 12 (10.4) | 10 (17.5) | 6 (7.7) | 3 (5.7) | 31
(10.2) |
|||
| Y184F | Y | 42 (34.1) | 15 (27.8) | 31 (38.8) | 22 (37.9) | 110
(34.9) |
0.574 | |
| F | 81 (65.9) | 39 (72.2) | 49 (61.2) | 36 (62.1) | 205
(65.1) |
|||
| Pfdhfr | N51I | N | 28 (20.6) | 9 (16.7) | 6 (8.0) | 10 (18.9) | 53
(16.6) |
0.124 |
| I | 108 (79.4) | 46 (83.3) | 69 (92.0) | 43 (81.1) | 266
(83.4) |
|||
| C59R | C | 12 (17.9) | 5 (16.7) | 12 (15.4) | 3 (5.8) | 32
(14.1) |
0.256 | |
| R | 55 (82.1) | 25 (83.3) | 66 (84.6) | 49 (94.2) | 195
(85.9) |
|||
| S108N | S | 17 (13.0) | 5 (9.1) | 4 (5.1) | 4 (7.5) | 30
(9.5) |
0.280 | |
| N | 114 (87.0) | 50 (90.9) | 74 (94.9) | 49 (92.5) | 287
(90.5) |
|||
| Pfdhps | A437G | A | 16 (12.7) | 5 (9.1) | 1 (1.3) | 7 (14.0) | 29
(9.4) |
0.031 |
| G | 110 (87.3) | 50 (90.9) | 77 (98.7) | 43 (86.0) | 280
(90.6) |
|||
| K540E | K | 106 (99.1) | 54 (98.2 | 78 (100) | 52 (100) | 290
(99.3) |
- | |
| E | 1 (0.9) | 1 (1.8) | 0 (0) | 0 (0) | 2 (0.7) |
aMutated amino acid depicted in bold, b P-value based on Pearson chi-Square test or Exact chi-square test for categorical variables.