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. 2020 Mar 26;21(6):2475–2483. doi: 10.3892/mmr.2020.11041

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Copyright: © Ren et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Relative mRNA expression of SRA1, SREBP2, LDL-r and CD36 in the blood vessels of STZ-induced treated mice. Significant increases in mRNA relative expression of SRA1 and CD36, SREBP2 and LDL-r were observed in the blood vessels from STZ-induced treated mice, compared with the normal mice. However, EGCG (100 mg/kg, 200 mg/kg) was able to reduce the gene expression of SRA1 and CD36, SREBP2 and LDL-r in blood vessels. Comparisons were assessed with one-way ANOVA followed by Tukey's post hoc test. **P<0.01, ***P<0.001 vs. model group. SRA, scavenger receptor A; CD, cluster of differentiation; SREBP2, sterol regulatory element binding protein 2; LDL-r, low-density lipoprotein receptor; STZ, streptozotocin; EGCG, epigallocatechin-3-gallate.