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. 2020 Apr 1;21(6):2522–2532. doi: 10.3892/mmr.2020.11049

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — CCL11 blockade inhibits the 4T1 cell-induced proportion of CD4⁺CD25⁺Foxp3⁺ Treg cells and the release of IL-2 and TGF-β1 in vivo. BALB/c nude mice were intravenously injected with 4T1 cells and intraperitoneally injected with anti-CCL11 neutralizing (100 µg) every 48 h (n=6 per group). (A) Representative images of the histological inspection of mouse lungs at 21 days post-treatment. Scale bar, 100 µm. (B) Representative plots and (C) quantification of the proportion of CD4⁺CD25⁺Foxp3⁺ Treg cells, measured by flow cytometry. (D) Serum levels of CCL11, IL-2 and TGF-β1, measured by ELISA. ****P<0.0001 vs. the control group; ^####P<0.0001 vs. the 4T1 cell group. CCL11, C-C motif chemokine ligand 11; Foxp3, forkhead box P3; Treg, T regulatory; IL, interleukin; TGF, transforming growth factor.