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. 2020 Apr 8;21(6):2435–2442. doi: 10.3892/mmr.2020.11059

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Copyright: © Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — MEG3 regulates apoptosis of ADSCs. (A) After transfecting MEG3 into ADSCs, MEG3 expression in the MEG3-up group was significantly higher than that in the vector group, and MEG3 expression in the MEG3-down group was significantly lower than that in the NC group. (B) Apoptotic rate (UR+LR) was 7.04±1.10% in the control group, 9.44±0.52% in the vector group, 17.91±2.02% in the MEG3-up group, 10.28±1.31% in the NC group and 6.38±1.21% in the MEG3-down group. The apoptotic rate in the MEG3-up group was significantly higher than that in the vector group, and that in the MEG3-down group was lower than that in the NC group. (C) Compared with the vector group, the expression of p53 was significantly higher in the MEG3-up group. Compared with the NC group, the expression of p53 was significantly lower in the MEG3-down group. (D) Compared with the control group, Bax, caspase3 and caspase9 were upregulated in the MEG3-up group. Compared with the NC group, Bax, caspase3 and caspase9 were downregulated in the MEG3-down group. Compared with the vector group, Bcl-2 was downregulated in the MEG3-up group. Compared with the NC group, Bcl-2 was upregulated in the MEG3-down group. *P<0.05, **P<0.01. ADSC, adipose-derived stem cells; MEG3, maternally expressed gene 3; NC, negative control.