Table 4.
Univariate and Multivariate Analyses of Prognostic Factors in GC Patients
| Factors | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age(years) | 0.001 | 0.012 | ||
| <60 | 1 | 1 | ||
| ≥60 | 3.307 (1.688–6.478) | 2.406 (1.213–4.77) | ||
| Sex | 0.045 | |||
| Female | 1 | |||
| Male | 1.776 (1.013–3.115) | |||
| Tumor size (cm) | <0.001 | |||
| <3 | 1 | |||
| ≥3 | 3.495 (1.871–6.528) | |||
| Tumor Location | ||||
| Upper third | 0.894 (0.473–1.69) | 0.73 | ||
| Middle third | 1.496 (0.856–2.617) | 0.158 | ||
| Lower third | 1 | |||
| Histological grade | 0.446 | |||
| Well differentiated | 1 | |||
| Poorly differentiated | 0.77 (0.393–1.508) | |||
| FAR | <0.001 | |||
| <0.086 | 1 | |||
| ≥0.086 | 2.621 (1.618–4.244) | |||
| CEA (ng/mL) | 0.001 | |||
| <3.2 | 1 | |||
| ≥3.2 | 2.296 (1.421–3.71) | |||
| NLR | <0.001 | |||
| <2.17 | 1 | |||
| ≥2.17 | 3.063 (1.799–5.213) | |||
| CEA-FAR | ||||
| 0 | 1 | 1 | ||
| 1 | 2.87 (1.636–5.034) | <0.001 | 1.642 (0.922–2.923) | 0.092 |
| 2 | 4.918 (2.463–9.82) | <0.001 | 2.308 (1.13–4.716) | 0.022 |
| TNM Stage | ||||
| Ⅰ | 1 | 1 | ||
| Ⅱ | 5.609 (1.243–25.311) | 0.025 | 5.049 (1.106–23.057) | 0.037 |
| Ⅲ | 20.615 (5.023–84.615) | <0.001 | 18.759 (4.354–80.812) | <0.001 |
Note: CEA-FAR: CEA<3.2 and FAR<0.086 represent 0, CEA≥3.2 or FAR≥0.086 represent 1, CEA≥3.2 and FAR≥0.086 represent 2.
Abbreviations: GC, gastric cancer; CEA, carcinoembryonic antigen; FAR, fibrinogen/albumin ratio; TNM, tumor-node-metastasis; HR, hazard ratio; CI, confidence interval; NLR, neutrophil-to-lymphocyte ratio.