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. 2020 Apr 8;27(4):565–598. doi: 10.1089/cmb.2019.0302

FIG. 3.

FIG. 3.

Accuracy and RMSD of the phylogeny-free method as functions of tumor samples and regularization parameter. The red dashed line shows average overall accuracy (left panel) or RMSD (center and right panels) of NMF with random initialization. The black dashed line shows the performance of the all-diploid baseline solution. Since we cannot resolve mixture fractions for an all-diploid solution, we omit it from the mixture fraction results. Different bars show performance as a function of regularization parameter α of Equation (2) from 0.0 to 1.0 in increments of 0.2. The X-axis shows the number of tumor samples, and the Y-axis the average accuracy or RMSD. NMF, non-negative matrix factorization; RMSD, root mean square deviation.