FIG. 5.

Average accuracy and RMSD for the phylogeny-based method as functions of tumor samples and regularization parameter. The left panel shows the average accuracy of inferred copy numbers, the center panel average RMSD between inferred and true copy numbers, and the right panel average RMSD between the inferred and true mixture fractions. The black dashed line shows the performance of the all-diploid baseline solution. Since we cannot resolve mixture fractions for an all-diploid baseline, we omit it from the mixture fraction results. Bar plots show performance with different regularization parameters β of Equation (3) from 0.0 to 1.0 with increment of 0.2. The X-axis shows the number of tumor samples, and the Y-axis the average accuracy or RMSD.