Table 1.
Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of rapid antigen detection test BinaxNOW influenza AB® and BinaxNOW RSV® compared to gold standard RT-PCR tested in nasal washings of children between 0 and 5 years at Erasmus MC-Sophia from 2005 to 2013.
| Rapid antigen detection tests | Sensitivity (%) [95% confidence interval; CI] n | Specificity (%) [95% CI] n | PPV (%) [95% CI] n | NPV (%) [95% CI] n |
|---|---|---|---|---|
| BinaxNow Influenza AB® vs RT-PCR n = 521 | 68.6 [51–83] 24/35 | 95.8 [94–97] 466/486 | 54.5 [39–70] 24/44 | 97.7 [96–99] 466/477 |
| BinaxNow RSV® vs RT-PCR n = 514 | 79.4 [73–85] 162/204 | 98.4 [96–99] 305/310 | 97 [93–99] 162/167 | 88 [84–91] 305/347 |
| Samples obtained in respiratory virus season | ||||
| BinaxNow Influenza AB® vs RT-PCR n = 436 | 66.7 [48–82] 22/33 | 95.3 [93–97] 384/403 | 53.7 [37–69] 22/41 | 97.2 [95–99] 384/395 |
| BinaxNow RSV® vs RT-PCR n = 428 | 80 [74–85] 160/200 | 98 [96–100] 224/228 | 98 [94–99] 160/164 | 85 [80–89] 224/264 |