Figure 3.

Acute improvement in glucose tolerance depends on β‐cell SENP1. Oral glucose tolerance, and the area under the curve (AUC) of glucose responses in male littermate βSENP^+/+ (a; WT; n = 4, 4 mice), βSENP^+/− (b; HET; n = 6, 5 mice), and βSENP^{− / −} (c; KO; n = 8, 7 mice) mice at 1 hr following gavage of the DPPIV inhibitor MK‐0626 (3 mg/Kg). Loss of β‐cell SENP1 blunts the ability of DPPIV inhibition to improve glucose tolerance. Plasma insulin responses are shown at the 0 min (d) and 15 min (e) time points, and also normalized to measured glucose levels at these points (f,g). *‐p < .05, **‐p < .01, and ***‐p < .001 comparing vehicle control versus DPPIV inhibitor